Quantitative Mass Spectrometry has been developed for decades and allows to detect elements and molecules without labelling. ImaBiotech developed the quantitative aspects through many patents making ImaBiotech the worldwide leader in this field. QMSI changes the rules of the game of the pharmaceutical industry in all the therapeutic areas. The QMSI is translational and help to investigate where the drug and biomarkers are localized and support PK/PD relationship in preclinical and clinical stages.
What is it ?
The Quantitative Mass Spectrometry Imaging (QMSI) is a technique adapted to :
- Detection “target molecules (drugs, metabolites, lipids, endogenous metabolites, peptides and proteins) or elements (Zinc, Copper, Gold, Calcium, Iron, Gadolinium, etc.)”
- Localization “visualize molecules from 1µm spatial resolution with our new instruments”
- Quantification “Quantify detected molecules with accuracy and precision”
What are the advantages of Mass Spectrometry Imaging ?
Simultaneous localization and quantification of thousands of compounds
Accurate and precise methods have been proprietary of ImaBiotech under patents and know-how
From minutes to a few hours according to image size and resolution
Standardized & reproducible
Methods and technologies have been developed by ImaBiotech’s team to guarantee quality of the studies
Our Different Techniques
MALDI Imaging uses a Matrix Assisted Laser Desorption Ionization technique to detect intact molecules amino acids, metabolites, drugs, lipids and proteins from a tissue section. Also called Molecular histology technique, MALDI imaging is the most sensitive and robust technique that can detect simultaneously more than thousand molecules. ImaBiotech has developed process and software (Quantinetix and Multimaging) to make it more robust and quantitative. Variability has been measured to certify data interpretation and absolute quantification to guarantee the accuracy and precision to drug efficacy. Over the past years, ImaBiotech delivered more than 300 drug distribution and quantification studies using MALDI imaging and more than 100 publications in this field making ImaBiotech the #1 CRO.
LA-ICP-MS imaging is another Mass Spectrometry Imaging technique. Laser Ablation Inductively Coupled Plasma instrument allows to detect elements from a tissue section. Combined to MALDI imaging, LA-ICP MS imaging is a great tool to study the distribution and quantification of elements that are responsible for cell activities, growth, homeostasis such as Iron, Copper, Calcium, Zinc, etc…
This technique has been developed into the ImaBiotech’s platform and Multimaging software that allows the overlay of staining images made by LA-ICP MS imaging and MALDI imaging. ImaBiotech offers the same robustness and accuracy for ICP MS than for MALDI imaging using controls to guarantee data interpretations.
|Publication||Tryptophan-Kynurenine Pathway in Immuno-Oncology|
|Application Note #14||Imaging of elements and metals in biological tissues|