Molecular Imaging

Detect, localize & quantify molecules

Why QMSI?

Imaging Mass Spectrometry has been developed for decades and allows to detect elements and molecules without labeling (MALDI, LA-ICP or SIMS imaging) or with metal tags (MIBI, from Ionpath and Imaging Mass Cytometry from Fluigim). The benefits of all these techniques remains in a large multiplex capabilities and to also to quantification. Since 15 years, ImaBiotech’s team developed robust and quantitative methods through many patents and protocols making ImaBiotech the worldwide leader in this field. QMSI changes the rules of the game of the pharmaceutical industry in all the therapeutic areas. The QMSI is translational and help to investigate where the drug and biomarkers are localized and support PK/PD relationship in preclinical and clinical stages.

ImaBiotech performed 450 drug development studies using Mass Spectrometry Imaging and is able to guarantee the success of your future study using retrospective information and its experience

What is it ?

The Quantitative Mass Spectrometry Imaging (QMSI) is a technique developed for:

- the detection “target molecules (drugs, metabolites, lipids, endogenous metabolites, peptides and proteins) or elements (Zinc, Copper, Gold, Calcium, Iron, Gadolinium, etc.)”
- the localization “visualize molecules from 1µm spatial resolution with our new instruments”
- the quantification “Quantify detected molecules with accuracy and precision”

For What Benefits?

Label-free

Simultaneous localization and quantification of thousands of compounds

Quantitative

Accurate and precise methods have been proprietary of ImaBiotech under patents and know-how

Fast

From minutes to a few hours according to image size and resolution

Standardized & reproducible

Methods and technologies have been developed by ImaBiotech’s team to guarantee quality of the studies

Our Different Techniques

MALDI Imaging

MALDI Imaging uses a Matrix Assisted Laser Desorption Ionization technique to detect intact molecules amino acids, metabolites, drugs, lipids and proteins from a tissue section. Also called Molecular histology technique, Mass spectrometry imaging by MALDI imaging is the most sensitive and robust technique that can detect simultaneously more than thousand molecules. ImaBiotech has developed process and software (Quantinetix and Multimaging) to make it more robust and quantitative. Variability has been measured to certify data interpretation and absolute quantification to guarantee the accuracy and precision to drug efficacy. Over the past years, ImaBiotech delivered more than 450 drug distribution and quantification studies using MALDI imaging and more than 100 publications in this field making ImaBiotech the #1 CRO.

LA-ICP-MS Imaging

LA-ICP-MS imaging is another Mass Spectrometry Imaging technique. Laser Ablation Inductively Coupled Plasma instrument allows to detect elements from a tissue section. Combined to MALDI imaging, LA-ICP MS imaging is a great tool to study the distribution and quantification of elements that are responsible for cell activities, growth, homeostasis such as Iron, Copper, Calcium, Zinc, etc…This technique has been developed into the ImaBiotech’s platform and Multimaging software that allows the overlay of staining images made by LA-ICP MS imaging and MALDI imaging. ImaBiotech offers the same robustness and accuracy for ICP MS than for MALDI imaging using controls to guarantee data interpretations.