Metabolic syndrome is a cluster of metabolic disorders that disrupt normal metabolism, thus increasing metabolic risk factors for developing heart disease, stroke and type 2 diabetes mellitus. Thousands of enzymes participating in metabolic pathways carry out this process, by affecting the cell ability to perform biochemical reactions, as processing or transport of proteins (amino acids), carbohydrates (sugars and starches), or lipids (fatty acids). Pathogenesis of NonAlcoholic SteatoHepatitis (NASH), for example, implicates cell interactions between liver parenchymal and nonparenchymal cells as well as crosstalk between various immune cell populations in liver. All these key biological informations could be easily missed by homogenized sample analyses.
Aware, ImaBiotech platform provides a prerequisite, robust and accurate quantitative analysis of cells biochemical reactions, an important avenue to extract latent histologic disease signatures to correlate with molecular underpinnings and clinical outcomes.