MALDI-TOF MS Imaging of Controlled Release Implants

F. Kreye,1,2 G. Hamm,3 Y. Karrout,1,2 R. Legouffe,3 D. Bonnel,3, F. Siepmann,1,2 J. Siepmann1,2

PBP World Meeting 2012, Istanbul

1 University of Lille, College of Pharmacy, 3 Rue du Prof. Laguesse, 59006 Lille, France;
2 INSERM U 1008, Controlled Drug Delivery Systems and Biomaterials, 3 Rue du Prof. Laguesse, 59006 Lille, France;
3 ImaBiotech, MALDI Imaging Department, 70 Rue du Dr Yersin, 59120 Loos, France

Lipid implants offer a great potential for the controlled release of fragile drugs (e.g. proteins), avoiding drops in micro-pH (as associated with PLGA). However, yet little is known on the underlying drug release mechanisms and the inner structure of the systems as well as on changes thereof upon exposure to the release medium. MALDI-TOF MS (Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectroscopy) imaging provides an interesting opportunity to get novel insight into the spatial and temporal distributions of the compounds of advanced drug delivery systems [1,2].
The aim of this study was to apply MALDI-TOF MS imaging to lipid implants prepared by extrusion at room temperature before and after exposure to phosphate buffer.

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