Measure heterogeneity of the tissues
Tissue Heterogeneity is a usual parameter to consider while measuring pharmacokinetics and pharmacodynamics results. when Molecular imaging can’t provides enough information with sufficient sensitivity, Laser Capture Microdissection coupled to Liquid Chromatography Mass Spectrometry is a great alternative to measure molecular content of cells.
We integrated Laser Capture Micro-dissection into our histology department and bio-analytical department to allow the quantification of biomolecules at cellular level and reveal the cellular information.
Laser Capture Microdissection
Laser Capture Microdissection allows to delineate region of interest from histology section and capture the tiny piece of tissues into vials for further analysis. We can measure the concentration of drugs, biologics, small molecules as well as proteins, metabolites, mRNA or genes at the same time.
We offer innovative services including laser microdissection and High-end Mass Spectrometry and genomics platform to decipher the complexity of the tissues and measure the activity with accuracy. We keep the micro-environment and allows to select specific cells or region of interest in tissues. Then, we quantify Drugs, Biomarkers up to cellular level.
For Omics Studies
« Laser Mico-dissection is complementary technique. On daily basis, for me and my team, it enables us to quantify every molecules in specific regions of interests such as immune cells infiltrations or aggregates of bacteria ».