Imaging of elements and metals in biological tissues
LA-ICP-MS Imaging (Laser Ablation Inductively Coupled Plasma Mass Spectrome-try) is a recent technology that enables sensi-tive elemental and isotopic analysis to be performed directly on biological tissue samples. It has been used to study the distribu-tion of gadolinium, calcium, potassium, lithium, iron, copper, zinc, gold, aluminum, platinum, etc. LA-ICP-MS begins with a laser beam focused on the sample surface to generate ne particles – a process known as Laser Ablation. The ablated particles are then transported to the secondary excitation source of the ICP-MS instrument for digestion and ionization of the sampled mass. The excited ions in the plasma torch are subse-quently introduced to a mass spectrometer detector for both elemental and isotopic analysis.
LA-ICP-MS imaging is really interesting to investigate elemental analysis. This is a com-plementary technique that has been added to ImaBiotech’s platform of Multimaging. With Multimaging software, it is also possible to overlay ICP images with other MALDI, DESI, LESA Mass Spectrometry Imaging and immu-nohistochemistry images at cellular level. This makes a reliable set of tools and software to support your investigation.