Formulation screening phase

In the formulation screening phase, different drug delivery concepts are selected and compared to one another in terms of biodistribution and delivery. ImaBiotech can work directly on your selected solution or with some CDMO partners to compare the efficacy of penetration and distribution of your APIs. We have developed a unique approach by combining molecular imaging, histology and data science to generate some penetration profiles and/or biodistribution mapping in the tissue micro-environment. ImaBiotech can for example confirm the depth of penetration of an APIs in the skin following a topical application and compare it to some others formulations. By preserving the histological integrity of the biological tissue, it is today possible to carefully study and compare the impact of the formulation in each histological region and without any false positive (i.e. punch contamination on the skin).



Application NotesPublications   
Multimaging™ Applied to Skin Distribution Study: Applications in Dermatology for Pharmaceuticals and Cosmetics from Discovery to ClinicalMALDI imaging facilitates new topical drug development process by determining quantitative skin distribution profiles.

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