Focus on the skin structure to fight against acne, rosacea, psoriasis & more

Why are we using QMSI in dermatology?

Information on localization and penetration within the skin is important to understand the potential activity of drugs. We offer a label free technique of Mass Spectrometry Imaging to investigate the path of penetration, the concentration of drugs, metabolites and biomarkers.

What can be achieved?

Evaluation of Skin Penetration

  • In vitro or in vivo tests (Franz Cells, 3D models, fresh frozen tissue)
  • QMSI drug + metabolites
  • Histology
  • Overlay and Identification pathway of skin penetration

Overlay and Identification pathway of skin penetration

  • QMSI drug + metabolites
  • QMSI biomarkers
  • IHC biomarker / Target engagement

Identification of biomarkers

  • MSI of substructure of interest
  • Histology
  • Overlay and Identification pathway of skin penetration
  • Statistical analysis to identify biomarker involved in diseases or drug responses

Screening different formulations and compounds

  • Comparison of formulation effects onto the distribution by QMSI

 

How do we deliver local information in complex tissue?

  • Label free imaging at 10μm spectral resolution
  • Quantification of drug and metabolites down to the microenvironment of the tumor
  • Immuno-histology with the ability to overlay MSI, IHC and histological information within multimodal platform and dedicated software (Multimaging™, visit the dedicated page)
  • Efficacy and Safety Biomarkers monitoring
  • High Resolution Mass Spectrometers (R>200,000)
dermatology-Imaging

Where can we work?

  • STRATUM CORNEUM
  • EPIDERMIS
  • DERMIS
  • SEBACEOUS GLANDS
  • SWEAT GLANDS

We also provide more classical studies under GLP or Non-GLP environment

PK & PD studies

We propose PK and PD studies to support early to late stages drug discovery process (animals: rabbit, dog, swine or other species upon customer request).

  • Drug Disposition/Pharmacokinetics (ADME)
  • Pharmacodynamics
  • In Vitro and In Vivo Topical Absorption Studies (Franz Cells, 3D models, fresh frozen tissue)

Toxicology

We allow you to complete toxicological studies and propose several species such as dogs and rabbits and other non-rodent species.

  • Acute Toxicity
  • Subacute Toxicity (Repeated Dose)
  • Sub-chronic Exposure
  • Chronic Exposure

Models

We propose pathological models and naturally diseased animals for research (rabbit, dog …)

Contact us