Delineation of cell subpopulations and cell-cell interactions to determine correlations between drug response and tumor microenvironment in early-stage lung cancer

Introduction:

The dynamic interactions of cancer cells with their microenvironment consisting of stromal cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to stimulate the heterogeneity of cancer cell, clonal evolution and to increase the multidrug resistance ending in cancer cell progression and metastasis . Therefore, the understanding of the underlying cellular and molecular mechanisms governing the tumor microenvironment (TME) complexity can contribute to the development of efficient and safe therapeutic strategies to fight cancer . In the present study, using highmultiplexed immunohistochemistry, the TME of resected NSCLC patients, treated with the antiPD1 Pembrolizumab (Keytruda) as immune checkpoint inhibitor (ICI) adjuvant therapy was deciphered. These results highlighted the cell composition heterogeneity and the subsequent interactions to tumors cells between the patient that responded to the ICI therapy versus the one that progressed under it.

To read more about this poster which was presented at the American Association for Cancer Research (AACR) 2022 conference in New Orleans….




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