Finding new markers and monitoring targeted markers

    • Biomarker research or monitoring helps to characterize animal models (identify the contents of proteins, metabolites, lipids, etc…), compare animal models to human for a better translational research and finally improve drug development with precise medicine. Imaging mass spectrometry (IMS) in combination with standard microscopy imaging is a perfect way to assess spatial molecular arrangements in tissue sections providing thousands of different molecular images. A perfect way to perform a targeted or an untargeted approach to investigate the impact of drugs onto animal models and humans.In fact, ImaBiotech has a great experience in finding new biomarkers and monitoring targeted biomarkers, especially in oncology. Through Multimaging, ImaBiotech proposes different programs to identify, quantify and localize biomarkers related to therapy or diseases. The team has developed a huge expertise in metabolomics, lipidomics and proteomics with more than +100 publications in these fields and more than 2,500 bio-assays.
      The possibility to correlate distribution maps of multiple markers and drugs simultaneously with histological and clinical features makes it an ideal tool to deliver precision medicine.

Endpoints

  • Evaluation of targeted biomarker (localization, concentration, morphology) for preclinical and clinical samples
  • Identify new biomarkers in proteomics, metabolomics or lipidomics
  • Classification of patients based on tissue biomarkers (intensity or morphology parameters)

Expertise

We have experienced in biomarker research:

  • A team of statistician and bioinformatician with expertise in classification, computer vision and statistical tools
  • Number of scientists coming from the most recognized Lab, with expertise in proteomics, metabolomics and lipidomics
  • State-of-the-art platform with high resolution instruments
  • Statistical analysis based on intensity scale, absolute concentration or Morphometry analysis (Image feature analysis)
  • From statistical analysis (Multivariate, PCA, T-Test, ANOVA-test)
  • Data base of 2,500 identified molecules from rodent animals

Examples of biomarkers of efficacy:

Imaging Mass spectrometry

Technical Information

Tissue Samples

  • Tumor Models : melanoma, sarcoma, carcinoma, gliobalstoma (B16, CT26, P815 IDH1m).
  • EMT6 breast cancer
  • Human Biopsies
  • Kidney diseases
  • Liver diseases
  • Fibrosis tissues (cystic, lung)

Applied Technologies

2,500 bioassays represent molecules detected and quantified using Mass Spectrometry Imaging

  • Glycolysis
  • Tryptophan pathway (Kynurenine, Hydroxy-kynurenine, Tryptophan, Quinolinic Acid, Nicotinamide, 5-Hydroxyindole-3-acetic acid HAA)
  • Adenosine Pathway(adenosine, cAMP, Inosine, ATP, ADP, AMP, Hypoxanthine, Xanthine)
  • Arginine Biosynthesis (Arginine, Ornithine , Citrulline, Glutamate, etc…)
  • Phenylalanine & tyrosine
  • Krebs cycle
  • Amino Acids
  • Neurotransmitters (GABA, Dopamine, ACH, Glutamate, Serotonine, etc…) 450 Lipids (FA, TG, DG, gangliosides, etc…)
  • Sterols
  • Histone Acetylation

Objective

  • Biomarker Discovery & Monitoring

Contact us to discover more about our capacity