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News

  • SID 2017

    Come and meet Stefan Linehan and Charles Larson to discover all our capabilities. April 26- 29, 2017, in Oregon (...)

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  • AACR 2017

    Come and meet Stefan Linehan and Charles Larson to discover all our capabilities. April 1- 5, 2017, in Walter E. (...)

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Ophthalmology

ImaBiotech provides quantitative MALDI Imaging Mass Spectrometry services unmatched by any other classical technique: quantitative, label-free ocular distribution with high accuracy up to 20µm resolution.

Traditional drug pharmacokinetics and distribution with dissection can now be replaced by MALDI Imaging Mass Spectrometry, which offers precise localization and quantitation of parent drugs and metabolites. No more LCMS/MS method development for the various ocular tissues!


CLICK A SPECIFIC REGION OF INTEREST FOR MORE INFORMATION

Iridocorneal angle region

Optic nerve region

Retina-Choroid-Sclera region

Cornea region

Figure : Optical image of a sagittal section of eye, H.E. staining

Ophtalmology Customer MALDI MSI



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In Ophthalmology, we can study :

Target Engagement

PK/PD

Toxicity effects


Drug distribution and quantification
  • High resolution drug +metabolites imaging at 20µm
  • Quantify drug and metabolites in specific regions from the anterior to posterior chambers of the eye
  • Unknown metabolite research and identification

Pathologies

Eye Mass Spectrometry Imaging

  • Glaucoma
  • AMD
  • Dry eye
  • Diabetic retinopathy

Animal species
  • Monkey
  • Rabbit
  • Rat
  • Mouse

Regions of interest
  • Cornea
  • Iris
  • Iridocorneal angle
  • Sclera, choroid, retina
  • Vitreous & Aqueous humor
  • Optic nerve