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News

  • SID 2017

    Come and meet Stefan Linehan and Charles Larson to discover all our capabilities. April 26- 29, 2017, in Oregon (...)

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  • AACR 2017

    Come and meet Stefan Linehan and Charles Larson to discover all our capabilities. April 1- 5, 2017, in Walter E. (...)

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Gastroenterology

In just a few days, evaluate and compare drug distribution and concentration in various parts of the intestine.

ImaBiotech provides quantitative MALDI Imaging Mass Spectrometry services unmatched

by any other classical technique: quantitative label-free drug distribution in gastroenterology studies with high accuracy up to 20µm resolution.

Classical drug pharmacokinetics and distribution with dissection can now be advantageously replaced by MALDI Imaging Mass Spectrometry allowing the accurate localization and quantitation of parent drug and metabolites. No LCMS/MS method development for each specific Intestine tissue!

Gastroenterology Mass spectrometry Imaging
Figure : Optical and MALDI Mass Spectrometry Images of the colon in a mouse treated with a drug candidate via oral administration. Section thickness: 12 µm; spatial resolution: 30 µm.


In Gastroenterology, we can study :
_ Target Engagement

PK PD Maldi MSIPK/PD

MSI Toxicology Maldi Toxicity effects


Drug distribution and quantification
  • High resolution drug and metabolites imaging at 20µm
  • Quantify drug and metabolites in different regions of the gastrointestinal tract
  • Coupled with whole body distribution to study overall and organ-specific localization
  • Unknown metabolite research and identification

Pathologies
  • Gastroenteritis
  • IBS - IBD
  • Crohn’s disease

Regions of interest
  • Ileum
  • Jejunum
  • Duodenum
  • Colon
  • Mucosa
  • Submucosa
  • Brunner glands

Animal species
  • Rat
  • Mouse

Metabolomics
  • Study the impact of treatment onto endogenous metabolites
  • Support the validation of pharmacological animal models