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ImaBiotech website in English
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News

  • ASMS 2017

    Come and meet Rima Ait-Belkacem and Jonathan Stauber to discover all our capabilities. June 4- 8, 2017, in (...)

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  • Webinar on Immuno-Oncology by Rima AIT-BELKACEM, PhD

    The webinar titled “Immuno-Oncology: Tryptophan-Kynurenine Microenvironment Tumor Metabolites Pathway Highlighted by (...)

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Dermatology & Cosmetics

ImaBiotech provides precise information about drug penetration in the skin substructures, as well as supportive information about efficacy and potential toxicity!

The better understanding of drug penetration and effects through the various layers of the skin may play a key role in the drug development process especially for pharmaceutical, cosmetic and dermatological products. In this context, ImaBiotech provides useful and precise information about exogenous compounds’targeting the skin substructures (at the micrometer scale), their amount (using quantitative MSI), their impact on endogenous molecules of the skin tissue (small endogenous metabolites, lipids, peptides or proteins) and their potential adverse effects (inflammatory or toxicity response).

MSI Dermatology Imabiotech

Customers ImaBiotech Dermatology




In dermatology, we can study :

Target Engagement

PK-PD MSIPK/PD

Toxicity effects with Mass Spectrometry Imaging ImaBiotechToxicity effects



Benefits
  • Better lead selection in comparing drug penetration in the skin substructures
  • Better target engagement assessment at cellular level without labelling
  • Better toxicity assessment with identification of the possible causes of toxicity
  • Disease state markers assessment

Advantages
  • High resolution drug and metabolites imaging at 20μm
  • Quantify drug and metabolites in different layers of the skin
  • Unknown metabolite research and identification
  • Efficacy and toxicity biomarkers monitoring
  • Molecular histology and segmentation

Regions of interest
  • Psoriasis
  • Rosacea
  • Onychomycosis
  • Atopic & Seborrheic dermatitis
  • Acne
  • Skin Senescence

Regions of interest
  • Stratum Corneum
  • Epidermis
  • Dermis
  • Sebaceous glands

    Customers ImaBiotech Dermatology 2

Download our application note

Skin Mass Spectrometry Imaging